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Mechanism of rotenone toxicity and neurodegenerative effect
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Description
Rotenone shows its toxicity in dopaminergic neurons by inhibiting mitochondrial respiration and increasing oxidative stress. Due to its lipophilic structure, rotenone penetrates brain, blocks electron transfer from complex I to ubiquinone and stops ATP production. Inhibition of the passage of electrons to complex II increases the mitochondrial permeability potential, induces mitochondrial damage, endoplasmic reticulum stress and neurodegeneration .
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