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BioRender Template
Mechanism of T-DXd action in HER2 Cancers
Creator
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Description
This figure illustrates the mechanism of trastuzumab deruxtecan (T-DXd) in HER2-expressing tumours. (A) T-DXd binds HER2, blocking dimerisation and signalling. (B) The complex is internalised via endocytosis, ensuring targeted payload delivery. (C) The membrane-permeable drug diffuses to nearby cells, producing a ‘bystander effect’. (D) The topoisomerase I inhibitor induces DNA damage, apoptosis, and ADCC. Black arrows show process flow; red = apoptosis; green = immune killing.
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