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Mechanisms of T-regs on neuroinflammation
Creator
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Description
Mechanisms underpinning the effect of increased regulatory T cells on neuroinflammation. Regulatory T cells (Tregs) modulate many pathways in AD to reduce inflammation. Tregs modulate astrogliosis to prevent reactive astrocyte. They also inhibit microgliosis. Both functions lead to reduced amyloid-beta plagues and neurofibrillary tangles of tau protein. Furthermore, Tregs produce many anti-inflammatory cytokines such as interleukin-10 (IL-10) and Transforming Growth Factor beta TGF-β 101.
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