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Mechanisms related to ferroptosis

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Yue Shi

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Description: A. The System Xc−-GSH-GPX4 axis is a classic antioxidant pathway. GPX4 reduces L-OOH in membranes to non-toxic L-OH, thereby inhibiting lipid peroxidation. B. Fe3+ is transported to endosomes via TF and TFRC. Subsequently, Fe3+ is reduced to Fe2+ and released into LIP by STEAP3 and DMT1. NCOA4 binds ferritin and mediates ferritinophagy. C. PUFAs are converted to PUFA-PL via ACSL4 and LPCAT3. PUFA-PL is oxidized to PL-PUFA-OOH via Fe2+, ALOXs, or PORs, thus, driving ferroptosis.

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A. The System Xc−-GSH-GPX4 axis is a classic antioxidant pathway. GPX4 reduces L-OOH in membranes to non-toxic L-OH, thereby inhibiting lipid peroxidation. B. Fe3+ is transported to endosomes via TF and TFRC. Subsequently, Fe3+ is reduced to Fe2+ and released into LIP by STEAP3 and DMT1. NCOA4 binds ferritin and mediates ferritinophagy. C. PUFAs are converted to PUFA-PL via ACSL4 and LPCAT3. PUFA-PL is oxidized to PL-PUFA-OOH via Fe2+, ALOXs, or PORs, thus, driving ferroptosis.

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