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BioRender Template
Mechanistic Pathway of Regorafenib Action in the STZ-induced Alzheimer’s Model
Description
Mechanistic pathway illustrating regorafenib's therapeutic actions in Alzheimer's disease. Regorafenib inhibits VEGFR/PDGFR signaling peripherally, enhancing insulin and GLP-1 levels, thereby improving systemic glucose metabolism. Centrally, it strengthens PI3K/Akt signaling, reduces GSK-3β activity, and decreases tau phosphorylation, ultimately mitigating Alzheimer's pathology.
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