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Membrane Atg8ylation and Deatg8ylation Cycle

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Vojo Deretic, PhD

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Description: Membrane Atg8ylation represents covalent membrane modification by ubiquitin-like proteins of the mammalian Atg8-family proteins (ATG8s: LC3A, LC3B, LC3B2, LC3C, GABARAP, GABARAPL1, and GABARAPL2). The membrane Atg8ylation cycle is akin to the process of protein ubiquitination and deubiquitination. The ATG12–ATG5 conjugate combines with a membrane-binding component.

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Membrane Atg8ylation represents covalent membrane modification by ubiquitin-like proteins of the mammalian Atg8-family proteins (ATG8s: LC3A, LC3B, LC3B2, LC3C, GABARAP, GABARAPL1, and GABARAPL2). The membrane Atg8ylation cycle is akin to the process of protein ubiquitination and deubiquitination. The ATG12–ATG5 conjugate combines with a membrane-binding component.

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