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BioRender Template
MET Exon 14 Skipping Mutation in Lung Cancer
Description
This template compares normal versus aberrant splicing of the MET gene, showing exons 12-15 in the DNA, pre-mRNA, and mRNA stages. It illustrates how exon 14 skipping leads to loss of CBL binding, preventing MET receptor ubiquitination and causing increased protein levels and signal upregulation compared to normal degradation via lysosomes.
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