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BioRender Template
Primary Methamphetamine Mechanism of Action
Creator
s
Description
Methamphetamine enters the pre-synaptic cell via transporters (DAT, NET, or SERT) or passive diffusion and displaces monoamines (dopamine, norepinephrine, or serotonin respectively) from storage vesicles. The monoamines exit through their respective transports or by exocytosis, thus increasing the synaptic concentration. Because of the higher levels of monoamines in the synapse, receptors at the post-synaptic neuron are stimulated for a longer duration with a higher intensity.
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