Microfluidic Device for Electronic Discrimination of T cells by Activation State

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. A key component of host defense against infections (such as COVID-19) is the activation of cellular immunity, characterized by T cell responses. When naïve T cells are activated, they go through changes in physioelectric properties. This microfluidic chip uses dielectrophoretic forces to electronically detect and separate naïve and activated T cells. This point-of-care device is both a rapid diagnostic for infection and a therapeutic tool to enrich for immuno-reactive T cells.

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