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BioRender Template
MicroRNA Biogenesis Pathway
Creator
s
Description
The steps of the microRNA biogenesis pathway. pri-miRNAs are transcribed by RNA polymerase II. pri-miRNAs are processed into precursor miRNAs pre-miRNAs via Drosha, which cleaves the hairpin structures at their base. Exportin 5 mediates the export of pre-miRNAs from the nucleus to the cytoplasm. DICER, cuts pre-miRNAs into duplexes One strand of this duplex is incorporated into the RNA-induced silencing complex (RISC), leading to gene silencing, while the other strand is typically degraded.
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