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Microtubule Dynamic Instability
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Description:
Microtubules depolymerize about 100 times faster from an end containing GDP-tubulin than from one containing GTP-tubulin. A GTP cap favors growth,
but if it is lost, then depolymerization ensues. Individual microtubules can therefore alternate between a period of slow growth and a period of rapid disassembly, a phenomenon called dynamic instability.
Updated
July 2026
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Microtubules depolymerize about 100 times faster from an end containing GDP-tubulin than from one containing GTP-tubulin. A GTP cap favors growth,
but if it is lost, then depolymerization ensues. Individual microtubules can therefore alternate between a period of slow growth and a period of rapid disassembly, a phenomenon called dynamic instability.