miRNA biogenisis
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Description:
This template traces plant miRNA biogenesis starting with Pol II transcription of the MIR gene into a pri-miRNA hairpin, which is processed inside a nuclear dicing body by the DCL1, HYL1, and SE proteins into a pre-miRNA and then a miRNA duplex. The duplex is methylated by HEN1, exported to the cytoplasm through HST, and its guide strand loads into an AGO-containing RISC complex to bind a target mRNA.
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This template traces plant miRNA biogenesis starting with Pol II transcription of the MIR gene into a pri-miRNA hairpin, which is processed inside a nuclear dicing body by the DCL1, HYL1, and SE proteins into a pre-miRNA and then a miRNA duplex. The duplex is methylated by HEN1, exported to the cytoplasm through HST, and its guide strand loads into an AGO-containing RISC complex to bind a target mRNA.