Mitophagy
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Description:
This template shows how oxidative stress and increased metabolic activity generate reactive oxygen species that damage mitochondria, triggering either PARKN-mediated mitophagy for cell survival or, when damage overwhelms repair, cytochrome c leakage that activates Bax, Bim, and the apoptosis cascade. This pathway leads to cell death and downstream effects on nearby glial cells.
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This template shows how oxidative stress and increased metabolic activity generate reactive oxygen species that damage mitochondria, triggering either PARKN-mediated mitophagy for cell survival or, when damage overwhelms repair, cytochrome c leakage that activates Bax, Bim, and the apoptosis cascade. This pathway leads to cell death and downstream effects on nearby glial cells.