mitophagy and CRC
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This template shows mitophagy proteins involved in colorectal cancer, tracing how NLRs, PARK7, STAT3, Kras, and SIRT3 regulate mitochondrial biogenesis and deacetylation of FOXO3a, PINK1, and Parkin. It maps PINK1/Parkin-mediated mitophagy through the autophagosome-lysosome route alongside PINK1 signaling through p53 and HIF-1alpha to the TCA cycle, and BNIP, NIX, and FUNDC1 mediated mitophagy under hypoxia.
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This template shows mitophagy proteins involved in colorectal cancer, tracing how NLRs, PARK7, STAT3, Kras, and SIRT3 regulate mitochondrial biogenesis and deacetylation of FOXO3a, PINK1, and Parkin. It maps PINK1/Parkin-mediated mitophagy through the autophagosome-lysosome route alongside PINK1 signaling through p53 and HIF-1alpha to the TCA cycle, and BNIP, NIX, and FUNDC1 mediated mitophagy under hypoxia.