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Modulating effects of OSM and STAT3 on IFNγ-STAT1 and GM-CSF-STAT5 activation in trophoblast cells.
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Description
This figure describes the dependence of OSM for STAT3 in the direct regulation of βhCG but not E-cadherin expression. Also, OSM-induced STAT3 activation as a main molecular mechanism for the regulation of IFNγ-STAT1 and GM-CSF-STAT5 signaling pathways’ activation in trophoblast cells. Other mechanisms may involve TGFβ1-SMAD2 signaling pathway activation, and/or the recruitment of SOCS1 and SOCS3 proteins; to modulate inflammatory response and preserve trophoblast cell functions.
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