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Molecular resurrection work flow from ancient DNA to anticancer compound

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oshi Jnubotany

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Description: A conceptual overview illustrating the step-by-step process of identifying and resurrecting biosynthetic gene clusters from ancient DNA for anticancer drug discovery. The workflow integrates ancient genome analysis, synthetic gene design, expression in model organisms, compound isolation, structural characterization via LC-MS/NMR, and pharmacological validation using cancer cell lines and molecular docking. Adapted for clarity and impact in high-throughput natural product screening platforms.

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A conceptual overview illustrating the step-by-step process of identifying and resurrecting biosynthetic gene clusters from ancient DNA for anticancer drug discovery. The workflow integrates ancient genome analysis, synthetic gene design, expression in model organisms, compound isolation, structural characterization via LC-MS/NMR, and pharmacological validation using cancer cell lines and molecular docking. Adapted for clarity and impact in high-throughput natural product screening platforms.

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