Monocyte Differentiation
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Description:
This template shows how heterogeneous monocytes differentiate along two paths depending on GM-CSF or M-CSF signaling. GM-CSF with IFN-gamma and LPS drives M1 macrophages that release pro-inflammatory cytokines like IL-1beta, IL-6, IL-12, and TNF-alpha, while M-CSF with IL-4, IL-10, or immune complexes drives M2a, M2b, and M2c macrophages involved in inflammation resolution, tissue repair, and remodeling.
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This template shows how heterogeneous monocytes differentiate along two paths depending on GM-CSF or M-CSF signaling. GM-CSF with IFN-gamma and LPS drives M1 macrophages that release pro-inflammatory cytokines like IL-1beta, IL-6, IL-12, and TNF-alpha, while M-CSF with IL-4, IL-10, or immune complexes drives M2a, M2b, and M2c macrophages involved in inflammation resolution, tissue repair, and remodeling.








