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BioRender Template
Multiple TGF-β Regulatory Networks to Control the Tumor Immune Microenvironment
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s
Description
A) TGF-β induces immunosuppressive effects on CD8+ T cells both directly and indirectly, through cancer cell signaling and Treg polarization.
B) TGF-β directly and indirectly inhibits NK cell cytotoxic function.
C) TGF-β induces M2 polarization and immunosuppressive function in macrophages and CAFs.
D) TGF-β regulates the immune system's anti-tumor and pro-tumor responses by acting on these cell types.
Adapted from Fig. 6, Proactive and reactive roles of TGF-β in cancer.
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