BioRender Template
Neurons Regulate the Inflammatory Milieu
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Description:
Neurons both activate inflammation via release of HMGB1 and other pro-inflammatory molecules, as well as inhibit inflammation via acetylcholine release from vagal nerve fibers (the inflammatory reflex). However, these actions also feedback upon neurons to provide inhibition (red dashed line) to counter-balance further amplification (blue solid line) of inflammation.
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August 2026
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Neurons both activate inflammation via release of HMGB1 and other pro-inflammatory molecules, as well as inhibit inflammation via acetylcholine release from vagal nerve fibers (the inflammatory reflex). However, these actions also feedback upon neurons to provide inhibition (red dashed line) to counter-balance further amplification (blue solid line) of inflammation.