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Neuroprotective effet of Cabergoline and Mdivi-1 (Drp1 inhibitor) in Morphine-addicted cells

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Mina Makvand

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Description: Chronic morphine was found to downregulate MOR and DRD2, increasing α-synuclein, MEK-2, and β-arrestin2 expression in neural cells, leading to increased demand for dopamine, receptor desensitization, and development of neuroadaptation. Drp1 levels rose in morphine-addicted cells, disturbing the autophagy-apoptosis balance. Combining Cabergoline-Mdivi-1 significantly reduced autophagy-apoptosis, decreased ROS, and increased TAC and BDNF.

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Chronic morphine was found to downregulate MOR and DRD2, increasing α-synuclein, MEK-2, and β-arrestin2 expression in neural cells, leading to increased demand for dopamine, receptor desensitization, and development of neuroadaptation. Drp1 levels rose in morphine-addicted cells, disturbing the autophagy-apoptosis balance. Combining Cabergoline-Mdivi-1 significantly reduced autophagy-apoptosis, decreased ROS, and increased TAC and BDNF.

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