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Neutralizing Antibodies Against Venezuelan Equine Encephalitis Virus (VEEV) Aerosol
Creator
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Description
This figure depicts key findings on neutralizing monoclonal antibodies (mAbs) against Venezuelan equine encephalitis virus (VEEV). Potent mAbs isolated from mice and a human bind distinct antigenic sites in the A or B domains of the E2 glycoprotein, blocking viral attachment, fusion, and egress. A 3.2-Å cryo-EM structure shows B domain engagement cross-links spikes, inhibiting fusion. Prophylactic and therapeutic mAbs protected mice from lethal aerosol VEEV challenge.
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