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Neutrophil Extracellular Traps: How HIV Protects the Pre-eclamptic Placenta
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Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
In pre-eclamptic placentae, syncytiotrophoblast microparticles (STBM) triggers the release of neutrophil extracellular traps (NETs). Subsequent neutrophil migration and degranulation lead to placental apoptosis and elevated STBM release. In HIV co-infected placentae, the HIV viral evasion mechanism triggers the release of interleukin-10 by the pre-eclamptic decidual reservoir of dendritic cells. This suppresses NETs and prevents placental apoptosis.
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