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NKp46 signalling pathway
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Description:
NKp46 is an activating receptor on NK cells that recognizes pathogen- or tumor-specific ligands. Upon ligand binding, it triggers signaling through adaptor proteins containing ITAMs, leading to the activation of downstream pathways like PI3K-Akt, ERK, and PLCγ, which promote NK cell cytotoxicity and cytokine production. This process enables NK cells to kill infected or malignant cells and enhance immune responses.
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August 2026
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NKp46 is an activating receptor on NK cells that recognizes pathogen- or tumor-specific ligands. Upon ligand binding, it triggers signaling through adaptor proteins containing ITAMs, leading to the activation of downstream pathways like PI3K-Akt, ERK, and PLCγ, which promote NK cell cytotoxicity and cytokine production. This process enables NK cells to kill infected or malignant cells and enhance immune responses.