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BioRender Template
NMDA Receptor Acts as a Coincidence Detector by Displacing Mg²⁺ After Slight Depolarization
Creator
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Description
The diagram shows the need for 2 conditions to allow ion conduction in NMDA receptors: ligand binding (glutamate or co-agonist glycine) and membrane depolarization (Mg+2 displacement mediated by AMPA receptor activation). The consequence is an influx of Ca+2 and Na+ that plays a significant role in synaptic plasticity and downstream signaling pathways, such as long-term potentiation (LTP).
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