BioRender Template

Non-Phagocytic Nanoparticle Internalization Pathways

Created by

Kanlaya Katewongsa

•

BioRender Team

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Description:

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. This figure depicts the three major non-phagocytic cellular internalization pathways of nanoparticles (NPs): macropinocytosis, clathrin-mediated endocytosis and caveolae-mediated endocytosis. The first two pathways generally lead to lysosomal degradation, while NPs entered via caveolae-mediated pathway can sometimes escape fusion with lysosome. Therefore, designing NPs to enter through caveolae-mediated pathway can increase the chances of successful drug delivery.

Updated

August 2026

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