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BioRender Template
Novel Nanoparticles Target Oncogenic Long Non-Coding RNA for Cancer Therapy
Creator
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Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
Systemic nanoparticle therapy suppresses breast tumors through RNA interference (RNAi) of long non-coding RNA DANCR. PEG and RGD peptide improve biocompatibility and tumor uptake of the ECO/siDANCR nanoparticles, respectively. After endosomal escape at low pH, the nanoparticles release siDANCR, which is used by RNA-Induced Silencing Complex (RISC) to degrade cellular DANCR, thus preventing tumorigenic chromatin changes, epithelial-mesenchymal transition (EMT), and phosphorylation of oncokinases.
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