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Nutritional immunity with regards to zinc.
Creator
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Description
Keratinocytes and the cells of the mucosal layers secreted large amounts of the S100A7 homodimer called psoriasin. Within the body cells release calprotectin which binds Zn2+ in addition to other divalent metals such as Mn2+, Fe2+ and Ni2+. Zn2+ is imported into the innate immune cells by the ZIP-family of transporters and then bound by metallothionein which also circulates in the blood along with calprotectin and psoriasin.
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