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Outside-in and Inside-out Integrin Signaling Pathways
Description
This template compares outside-in integrin signaling, where ligand binding to the alpha/beta integrin heterodimer at the ECM drives cell polarity, survival, and gene expression, to inside-out signaling. In inside-out signaling, intracellular talin and kindlin bind an inactive bent integrin to activate it, promoting cell adhesion, migration, and ECM assembly.
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