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Overview of the SUMOylation cycle.
Description
The Sumo genes encode prepeptides that are cleaved and activated by SENP proteases to reveal a GG diglycine motif.
The GG motif in free, mature SUMO forms a thioester bond with the E1 activating complex.
The SUMO group is next transferred to the E2 conjugating enzyme UBC9 which transfers the SUMO group to the target protein with the aid of E3 ligases.
Multiple SUMO subunits can be linked to form a poly-SUMO tail.
SUMO can be released from target proteins by SENPs or other SUMOylases.
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