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Peptidoglycan Biosynthesis Pathway in Streptococcus pneumoniae

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Anna York

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BioRender Team

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Description: This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. UDP-N-acetylmuramyl pentapeptide (UDP-MurNAc-5P) is formed by the sequential action of the Mur ligases in the cytoplasm. At the membrane, MraY adds UDP-MurNAc-5P to undecaprenyl-phosphate forming Lipid I, which is then converted to Lipid II by MurG. MurT/GatD amidate the second position of the peptide stem and a dipeptide branch may be appended by MurM and MurN. MurJ flips Lipid II (branched & unbranched) across the membrane and penicillin-binding-proteins (PBPs) produce mature peptidoglycan.

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This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. UDP-N-acetylmuramyl pentapeptide (UDP-MurNAc-5P) is formed by the sequential action of the Mur ligases in the cytoplasm. At the membrane, MraY adds UDP-MurNAc-5P to undecaprenyl-phosphate forming Lipid I, which is then converted to Lipid II by MurG. MurT/GatD amidate the second position of the peptide stem and a dipeptide branch may be appended by MurM and MurN. MurJ flips Lipid II (branched & unbranched) across the membrane and penicillin-binding-proteins (PBPs) produce mature peptidoglycan.

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