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Perineuronal net composition
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Description:
Perineuronal nets (PNNs) consist of a backbone of hyaluronan to which different chondroitin sulfate proteoglycans (CSPGs) bind. CSPGs consist of a core protein and a chondroitin sulfate glycosaminoglycan (CS-GAG) chains. The CSPGs-hyaluronan bindings are stabilized by linking proteins. The extracellular matrix glycoprotein tenascin- R further links the CSPGs to each other. They form a structural brake to limit synaptic plasticity and capture molecules like Semaphorin 3A and OTX2.
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August 2026
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Perineuronal nets (PNNs) consist of a backbone of hyaluronan to which different chondroitin sulfate proteoglycans (CSPGs) bind. CSPGs consist of a core protein and a chondroitin sulfate glycosaminoglycan (CS-GAG) chains. The CSPGs-hyaluronan bindings are stabilized by linking proteins. The extracellular matrix glycoprotein tenascin- R further links the CSPGs to each other. They form a structural brake to limit synaptic plasticity and capture molecules like Semaphorin 3A and OTX2.