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PI3K Pathway in Cancer
Description
This template shows the PI3K signaling pathway in cancer, tracing growth factor and chemokine signaling through RTKs and GPCRs to activate RAS/RAF/MEK/ERK and PI3K/AKT/mTOR pathways. It shows how PTEN inhibits PIP3 production and how downstream signaling through TSC1/2 and mTOR promotes cancer cell growth, proliferation, survival, motility, and migration.
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