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BioRender Template
Piezo1 Endothelium Signaling
Description
This template shows how endothelial Piezo1 channels respond differently to increased flow, laminar flow, and turbulent flow, activating distinct downstream signaling molecules such as calpain, MT1-MMP, Akt, eNOS, ATP, and NF-kB. These signals lead to outcomes including vasoconstriction, endothelial cell alignment, capillary barrier disruption, sprout formation, atheroprotective vasodilation, and atherogenic inflammation.
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