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BioRender Template
PKR Mechanism of Action
Creator
s
Description
Protein kinase R (PKR) is a component of cell innate immunity against viruses that contain or produce double-stranded RNA (dsRNA). When such a virus (for example, a rotavirus) invades a cell, its dsRNA binds the PKR and makes it dimerise. The dimerised PKR acquires the kinase activity and phosphorylates the alpha subunit of eIF2, which, in turn, stops translation in the cell.
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