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Platelet induce metastasis via transfer of 12-lipoxygenase

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Paola Patrignani

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Description: The interaction of platelets and cancer cells induces the release of microparticles containing 12-lipoxygenase, which is transferred to the cancer cells that generate 12-HETE. 12-HETE is then esterified to membrane phospholipids, and this phenomenon is associated with the acquisition of epithelial-mesenchymal transitions and migratory properties leading to metastasis.

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The interaction of platelets and cancer cells induces the release of microparticles containing 12-lipoxygenase, which is transferred to the cancer cells that generate 12-HETE. 12-HETE is then esterified to membrane phospholipids, and this phenomenon is associated with the acquisition of epithelial-mesenchymal transitions and migratory properties leading to metastasis.

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