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Positive feedback loop mechanism between oxidative stress and NF-κB activation

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Lynn 鲁

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Description: In the absence of stimulation, NF-κB is bound in the cytoplasm by the inhibitory protein IκBα. In monocytes and microglial cell lines, IκBα is degraded when cells are stimulated by, for example, lipopolysaccharide (LPS , LPS) or interferon γ (Interferon γ,IFN γ), releasing subunits of NF-κB, such as p65/RelA, which allow it to enter the nucleus and activate the expression of downstream genes, such as NOX2, and in the case of NOX2 expression is inhibited in cells overexpressing IκBα.

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What does the Positive feedback loop mechanism between oxidative stress and NF-κB activation template show?

In the absence of stimulation, NF-κB is bound in the cytoplasm by the inhibitory protein IκBα. In monocytes and microglial cell lines, IκBα is degraded when cells are stimulated by, for example, lipopolysaccharide (LPS , LPS) or interferon γ (Interferon γ,IFN γ), releasing subunits of NF-κB, such as p65/RelA, which allow it to enter the nucleus and activate the expression of downstream genes, such as NOX2, and in the case of NOX2 expression is inhibited in cells overexpressing IκBα.

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