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Presynaptic Long-term Potentiation (LTP)
Description
This template shows presynaptic long-term potentiation at a glutamatergic synapse, tracing calcium influx through voltage-gated channels that activates adenylate cyclase, cAMP, and PKA signaling acting on the proteins Rab3a and RIM1α. This pathway promotes synaptic vesicle binding and persistent glutamate release onto NMDA and AMPA receptors on the postsynaptic dendritic spine.
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