Properties of Oncolytic Viruses

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. Oncolytic viruses (OVs) selectively replicate in malignant cells, while normal cells remain unaffected due to viral clearance. Viral replication induces tumor cell lysis and the release of virus progeny. Additionally, oncolysis induces the release of antigens, leading to priming of T cells. Inflammation attracts T cells to the tumor. Further, OVs can be modified to encode transgenes, ensuring specific delivery to the tumor microenvironment and further stimulation of an antitumor immune response.

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