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BioRender Template
PTPN1/2 Inhibitor in Solid Tumors
Description
This template shows how PTPN1/2 inhibitors block the phosphatase from dephosphorylating STAT proteins downstream of cytokine receptor and JAK signaling, allowing sustained STAT phosphorylation and transcription. This enhanced signaling strengthens IFN-gamma activation in T cells, boosting dendritic cell effector function, antigen presentation from tumor cells, and natural killer cell activity against solid tumors.
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