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BioRender Template
PTPN1/2 Inhibitors Molecular Mechanism of Action
Description
This template shows how PTPN1/2 phosphatases normally dephosphorylate JAK and STAT proteins to limit cytokine receptor signaling and transcription. It illustrates how PTPN1/2 inhibitors block this phosphatase activity at multiple points, allowing sustained STAT phosphorylation, formation of the active STAT complex, and increased transcription.
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