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R-loops Form in GC-rich Regions
Description
This template shows RNA polymerase II transcribing DNA and forming an mRNA strand that can lead to R-loop formation, a GC-rich DNA-RNA hybrid structure. Side panels list the factors that promote R-loop removal, such as helicases, topoisomerases, and RNase H1, alongside factors that promote R-loop formation, such as replication stress, DNA damage, and RNA Pol II pausing, framed around a homeostasis balance.
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