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BioRender Template
RANKL/RANK/OPG Axis
Creator
s
Description
Major bone cytokines OPG (bone production) and RANKL (bone resorption) strongly regulate bone homeostasis. RANKL and OPG are produced by osteoblasts physiologically. Bone resorption is activated by RANKL binding to RANK on osteoclast precursors during osteoclastogenesis. The physiological
inhibitor of RANKL, OPG, blocks RANKL from binding to RANK, inhibiting osteoclastogenesis.
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