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RIG-I and MDA-5 Detect Cytosolic Viral RNAs

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Akiko Iwasaki

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BioRender Team

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Description: This template shows how RIG-I and MDA-5 detect viral RNA in the cytoplasm, with RIG-I recognizing ssRNA from viruses like influenza and MDA-5 recognizing dsRNA from viruses like picornaviruses, both activating MAVS and a downstream TBK-1/IKK-e and IRF-3 signaling cascade that induces type I interferons.

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What does the RIG-I and MDA-5 Detect Cytosolic Viral RNAs template show?

This template shows how RIG-I and MDA-5 detect viral RNA in the cytoplasm, with RIG-I recognizing ssRNA from viruses like influenza and MDA-5 recognizing dsRNA from viruses like picornaviruses, both activating MAVS and a downstream TBK-1/IKK-e and IRF-3 signaling cascade that induces type I interferons.

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