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Schematic diagram illustrating the potential anti-adherence mechanisms of modified silicone catheter

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Dalia Zahaby

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Description: Modified ZnO NPs grafted poly-acrylic acid silicone catheter can inhibit microbial adherence. The potential mechanisms illustrated in the scheme; 1- the antifouling activity of the grafted polymer; 2- the reactive oxygen species induced following the interaction of water and the ZnO NPs immobilized on modified silicone; 3- the partial dissolution and production of Zn ions which block the thiol group of the microbial cell membrane proteins; 4- downregulation of biofilm-associated genes.

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Modified ZnO NPs grafted poly-acrylic acid silicone catheter can inhibit microbial adherence. The potential mechanisms illustrated in the scheme; 1- the antifouling activity of the grafted polymer; 2- the reactive oxygen species induced following the interaction of water and the ZnO NPs immobilized on modified silicone; 3- the partial dissolution and production of Zn ions which block the thiol group of the microbial cell membrane proteins; 4- downregulation of biofilm-associated genes.

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