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Signaling pathways underlying Trans Vaccenic acid(TVA) and/or S63845-induced apoptosis in NPC cells

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Tamima akter Shorna

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Description: 1.TVA promotes NPC apoptosis by targeting the Akt/Bad signaling pathway. 2.TVA treatment induced Mcl-1 expression. 3. Mcl-1 inhibitor S63845 combinated with TVA have a synergistic effect. 4. Specific activation of Akt inhibited apoptosis and significantly attenuated the inhibitory effect of TVA.

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1.TVA promotes NPC apoptosis by targeting the Akt/Bad signaling pathway. 2.TVA treatment induced Mcl-1 expression. 3. Mcl-1 inhibitor S63845 combinated with TVA have a synergistic effect. 4. Specific activation of Akt inhibited apoptosis and significantly attenuated the inhibitory effect of TVA.

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