Simplified MAPK/ERK signalling
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This template shows the EGFR and EML4-ALK fusion signaling pathways converging on RAS, RAF, MEK1/2, and ERK to drive proliferation, differentiation, and survival. Targeted drugs are labeled at their points of inhibition, including gefitinib, canertinib, afatinib, and osimertinib for EGFR, crizotinib for EML4-ALK, and MRTX849 and sotorasib for RAS.
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This template shows the EGFR and EML4-ALK fusion signaling pathways converging on RAS, RAF, MEK1/2, and ERK to drive proliferation, differentiation, and survival. Targeted drugs are labeled at their points of inhibition, including gefitinib, canertinib, afatinib, and osimertinib for EGFR, crizotinib for EML4-ALK, and MRTX849 and sotorasib for RAS.