BioRender Template

Spared Nerve Injury (SNI)

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Hankyu Lee

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Description: The spared nerve injury (SNI) model is a rat model of peripheral neuropathic pain involving selective lesioning of two sciatic nerve branches, sparing the sural nerve. Unlike other models, it limits mixing of intact and degenerating axons, enabling precise behavioral testing. SNI induces rapid, long-lasting hypersensitivity to mechanical and thermal stimuli, offering a robust tool to study neuropathic pain mechanisms.

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What does the Spared Nerve Injury (SNI) template show?

The spared nerve injury (SNI) model is a rat model of peripheral neuropathic pain involving selective lesioning of two sciatic nerve branches, sparing the sural nerve. Unlike other models, it limits mixing of intact and degenerating axons, enabling precise behavioral testing. SNI induces rapid, long-lasting hypersensitivity to mechanical and thermal stimuli, offering a robust tool to study neuropathic pain mechanisms.

Is the Spared Nerve Injury (SNI) template free to use?

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