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BioRender Template
Stress Response Mechanism in Cells
Description
This template shows how physiopathological triggers such as low heme or viral dsRNA lead to eIF2-alpha phosphorylation, which blocks cap-dependent translation while allowing selective translation of ATF4. It also shows how PP1 complexes with CReP or GADD34 dephosphorylate eIF2-alpha, and how ALTF4 and GADD34 drive expression of stress-induced genes encoding chaperones, redox enzymes, and other protective proteins.
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