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BioRender Template
Striatal Acetylcholine - Midbrain Dopamine Dynamics
Creator
s
Description
Following a salient sensory stimulus, a unique dynamic occurs between striatal cholinergic interneurons (CINs) and midbrain dopaminergic neurons (DANs). CINs exhibit an initial excitation during which they release acetylcholine (ACh) which stimulates the axons of DANs. DANs release dopamine (DA) which inhibits CINs, resulting in a CIN pause. Once DA levels decrease, CINs rebound from the inhibition.
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