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BioRender Template
Structure and functions of the PTEN tumor supressor gene
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Description
Structure and functions of the PTEN tumor suppressor gene. (A) Schematic view of the PTEN protein with its different functional components. (B) Overview of PTEN protein structure and magnification of its active site pocket with the phosphoinositide substrate (PtdIns(1,3,4,5)P4 in the inside.
(C) General view of the PTEN/PI3K/AKT/mTOR pathway and main functions of PTEN within the nucleus. PTEN structure (Protein Data Bank (PDB) ID:1D5R) was obtained using the PDB Biorender tool.
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